Hydroxychloroquine has been used in combination with azithromycin in the treatment of COVID-19, particularly during the early stages of the pandemic. hydroxychloroquin.net hydroxychloroquine 200 mg This combination therapy was based on preliminary evidence suggesting potential synergistic effects against the virus. However, subsequent studies have questioned the efficacy and safety of this regimen, highlighting the need for rigorous clinical trials to evaluate its effectiveness in treating COVID-19.